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KMID : 0895820020120020005
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Journal of Oriental Rehabilitation Medicine
2002 Volume.12 No. 2 p.5 ~ p.0
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The Effect of Palmijihwang-tanggaomija and Exercise on the Glucose Metabolism in ZDF Rat Skeletal Muscle
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Noh Young-Hyun
Keum Dong-Ho
Lee Myeong-Jong
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Abstract
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Objective: The glucose transportation through intracellula needs a glocose transporter(GLUT). GLUT-4. The conjunction of GLUT-4 in intracellula comes from the process of vesicle-membrane fusion, VAMP-2, Syntaxin-4. Therefore, this study is to find out how Palmijihwang-tanggaomija and exercise influence on the metabolism in glucose transportation at skeletal muscle of ZDF rat with insulin resistance.
Methods and Materials: We used three male normal zucker rats and twelve male obese rats, both aged four-week. The group was divided in a normal lean group(N, n=3), obese control group (OC, n=3), obeses exercises group(OE, n=3), obese medication group(OM, n=3), obese exercise and medication group(OEM, n=3). Exercises consisted of treadmill with 27m/min speed for an hour a day, five days a week, for 8 weeks.
Results and Conclusion: The level of glucose in blood significantly increased only at the OC group and insulin level increased significantly at all groups and OE and OM group, the OM group, and the OE group showed significant decrease of it among obese groups. The level of GLUT-4 in Soleus increased significantly at the OEM group, the OE group, and the OM group. Only the OEM group showed significant increase of it among the obese groups. The level of GLUT-4 in Plantaris increased significantly at the OE group, The level of VAMP-2 , Syntaxin-4 in Soleus and Plantaris increased significantly at the OC group and the OEM group. The OE group and the OM group showed a significant decrease, while only the OEMgroup showed significant decrease of syntaxin-4 at Plantaris. In conclusoin, Palmijihwang-tanggaomija and exercise can be applied to the treatment and the prevention of non-insulin dependent diabetes mellitus through the improvement of the insuline resistance.
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KEYWORD
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glucose transporter, Non-insulin Dependent Diabetes Mellitus, insulin resistance, vesicle-membrane fusion
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